Article

Tyrosine kinase SRC-mediated YAP1-KLF5 module regulates cancer stemness and metastasis in TNBC

2022-07-19

Abstract excerpt

<title>Abstract</title> <p>SRC was the first identified oncogene, and its aberrant activation has been implicated as a driving event in tumor initiation and progression. However, its role in cancer stemness regulation and the underlying regulatory mechanism are still elusive. Here, we identified a YAP1 tyrosine phosphorylation-dependent YAP1-KLF5 oncogenic module, as the key downstream mediator of SRC kinase regu...

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Literature Corpus work: e539b214-8b87-56e3-935c-b097a19210e5
DOI: 10.21203/rs.3.rs-1793676/v1

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