miR-16 and miR-103 impact 5-HT4 receptor signalling and correlate with symptom profile in irritable bowel syndrome.

doi:10.1038/s41598-017-13982-0

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Article

miR-16 and miR-103 impact 5-HT4 receptor signalling and correlate with symptom profile in irritable bowel syndrome.

Scientific reports - 31 Oct 2017

Wohlfarth Carolin, Schmitteckert Stefanie, Härtle Janina D, Houghton Lesley A, Dweep Harsh, Fortea Marina, Assadi Ghazaleh, Braun Alexander, Mederer Tanja, Pöhner Sarina, Becker Philip P, Fischer Christine, Granzow Martin, Mönnikes Hubert, Mayer Emeran A, Sayuk Gregory, Boeckxstaens Guy, Wouters Mira M, Simrén Magnus, Lindberg Greger, Ohlsson Bodil, Schmidt Peter Thelin, Dlugosz Aldona, Agreus Lars, Andreasson Anna, D'Amato Mauro, Burwinkel Barbara, Bermejo Justo Lorenzo, Röth Ralph, Lasitschka Felix, Vicario Maria, Metzger Marco, Santos Javier, Rappold Gudrun A, Martinez Cristina, Niesler Beate

Abstract excerpt

Irritable bowel syndrome (IBS) is a gut-brain disorder involving alterations in intestinal sensitivity and motility. Serotonin 5-HT4 receptors are promising candidates in IBS pathophysiology since they regulate gut motor function and stool consistency, and targeted 5-HT4R selective drug intervention has been proven beneficial in subgroups of patients. We identified a single nucleotide polymorphism (SNP)...

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Identifiers

PMID: 29089619
DOI: 10.1038/s41598-017-13982-0
PMCID: PMC5665867

Genes

HTR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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