First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome.

doi:10.1093/hmg/ddn195

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Article

First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome.

Human molecular genetics - 1 Oct 2008

Kapeller Johannes, Houghton Lesley A, Mönnikes Hubert, Walstab Jutta, Möller Dorothee, Bönisch Heinz, Burwinkel Barbara, Autschbach Frank, Funke Benjamin, Lasitschka Felix, Gassler Nikolaus, Fischer Christine, Whorwell Peter J, Atkinson Wendy, Fell Catherine, Büchner Karl J, Schmidtmann Marco, van der Voort Ivo, Wisser Anna-Sophia, Berg Thomas, Rappold Gudrun, Niesler Beate

Abstract excerpt

Diarrhea predominant irritable bowel syndrome (IBS-D) is a complex disorder related to dysfunctions in the serotonergic system. As cis-regulatory variants can play a role in the etiology of complex conditions, we investigated the untranslated regions (UTRs) of the serotonin receptor type 3 subunit genes HTR3A and HTR3E. Mutation analysis was carried out in a pilot sample of 200 IBS patients and 100 healthy...

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PMID: 18614545
DOI: 10.1093/hmg/ddn195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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