Article
First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome.
Human molecular genetics - 1 Oct 2008
Kapeller Johannes, Houghton Lesley A, Mönnikes Hubert, Walstab Jutta, Möller Dorothee, Bönisch Heinz, Burwinkel Barbara, Autschbach Frank, Funke Benjamin, Lasitschka Felix, Gassler Nikolaus, Fischer Christine, Whorwell Peter J, Atkinson Wendy, Fell Catherine, Büchner Karl J, Schmidtmann Marco, van der Voort Ivo, Wisser Anna-Sophia, Berg Thomas, Rappold Gudrun, Niesler Beate
Abstract excerpt
Diarrhea predominant irritable bowel syndrome (IBS-D) is a complex disorder related to dysfunctions in the serotonergic system. As cis-regulatory variants can play a role in the etiology of complex conditions, we investigated the untranslated regions (UTRs) of the serotonin receptor type 3 subuni...
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