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Article

Genetic Variations in TrkB.T1 Isoform and Their Association With Somatic and Psychological Symptoms in Individuals With IBS.

The journal of pain - 1 Nov 2024

Hong Hyejeong, Mocci Evelina, Kamp Kendra, Zhu Shijun, Cain Kevin C, Burr Robert L, Perry James A, Heitkemper Margaret M, Weaver-Toedtman Kristen R, Dorsey Susan G

Abstract excerpt

Irritable bowel syndrome (IBS), a disorder of gut-brain interaction, is often comorbid with somatic pain and psychological disorders. Dysregulated signaling of brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), has been implicated in somatic-psychological symptoms in individuals with IBS. We investigated the association of 10 single-nucleotide polymorphisms (SNPs) in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Membrane Glycoproteins

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Share to Receptor, trkB

Source

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Identifiers

PMID: 39004388
DOI: 10.1016/j.jpain.2024.104634
PMCID: PMC11567289

Genes

BDNF
NTRK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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