Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions.

Nature communications - 30 Oct 2017

Dalin Martin G, Katabi Nora, Persson Marta, Lee Ken-Wing, Makarov Vladimir, Desrichard Alexis, Walsh Logan A, West Lyndsay, Nadeem Zaineb, Ramaswami Deepa, Havel Jonathan J, Kuo Fengshen, Chadalavada Kalyani, Nanjangud Gouri J, Ganly Ian, Riaz Nadeem, Ho Alan L, Antonescu Cristina R, Ghossein Ronald, Stenman Göran, Chan Timothy A, Morris Luc G T

Abstract excerpt

Myoepithelial carcinoma (MECA) is an aggressive salivary gland cancer with largely unknown genetic features. Here we comprehensively analyze molecular alterations in 40 MECAs using integrated genomic analyses. We identify a low mutational load, and high prevalence (70%) of oncogenic gene fusions. Most fusions involve the PLAG1 oncogene, which is associated with PLAG1 overexpression. We find FGFR1-PLAG1 in seven...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomics

Share to HEK293 Cells

Share to In Situ Hybridization, Fluorescence

Share to Oncogene Proteins, Fusion

Share to Receptor, Fibroblast Growth Factor, Type 1

Share to Salivary Gland Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 29084941
DOI: 10.1038/s41467-017-01178-z
PMCID: PMC5662567

Genes

PLAG1
TGFBR3
FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions.PMID 29084941Read ↗

Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusionsSemantic proximity Read ↗

Whole-Genome Sequencing of Common Salivary Gland Carcinomas: Subtype-Restricted and Shared Genetic Alterations.Semantic proximity Read ↗

Insights From Mutational and Transcriptomic Profiles in Epithelial-myoepithelial Carcinoma.Semantic proximity Read ↗

Targeted RNA sequencing in the routine clinical detection of fusion genes in salivary gland tumorsSemantic proximity Read ↗

Identification of Fusion Genes and Targets for Genetically Matched Therapies in a Large Cohort of Salivary Gland Cancer PatientsSemantic proximity Read ↗

Targeted next generation sequencing of parotid gland cancer uncovers genetic heterogeneity.Semantic proximity Read ↗

The landscape of gene fusions and somatic mutations in salivary gland neoplasms - Implications for diagnosis and therapy.Semantic proximity Read ↗

Mutational landscape of primary pulmonary salivary gland-type tumors through targeted next-generation sequencing.Semantic proximity Read ↗

Whole-Exome Sequencing of Salivary Gland Mucoepidermoid Carcinoma.Semantic proximity Read ↗

Expanding the Molecular Spectrum of Carcinoma Ex Pleomorphic AdenomaSemantic proximity Read ↗

The clinical outcome, pathologic spectrum, and genomic landscape of 454 cases of salivary mucoepidermoid carcinomaSemantic proximity Read ↗

Single-cell RNA sequencing identifies a paracrine interaction that may drive oncogenic notch signaling in human adenoid cystic carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.