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Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes

29 Oct 2017

Abstract excerpt

Unbiased, "nontargeted" metabolite profiling techniques hold considerable promise for biomarker and pathway discovery, in spite of the lack of successful applications to human disease. By integrating nontargeted metabolomics, genetics, and detailed human phenotyping, we identified dimethylguanidino valeric acid (DMGV) as an independent biomarker of CT-defined nonalcoholic fatty liver disease (NAFLD) in the...

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PMID: 29083323
DOI: 10.1172/jci95995

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