Article
[Analysis of the Neuraminidase Amino Acid Sequences of Influenza A/H1N1pdm09, A/H3N2, and B Viruses Isolated from Influenza Patients in the 2013/14 Japanese Influenza Season].
Fukuoka igaku zasshi = Hukuoka acta medica - 1 Aug 2015
Ikematsu Hideyuki, Chong Yong, Shirane Kenjiro, Toh Hidehiro, Sasaki Hiroyuki, Koga Yui, Matsumoto Shinya, Hotta Taeko, Uchiumi Takeshi, Kang Donchon
Abstract excerpt
BACKGROUND: Neuraminidase (NA) is an essential surface protein for influenza virus replication. NA inhibitors are commonly used for the treatment of influenza patients in Japan. Several mutations that reduce the effect of NA inhibitors have been reported. We sequenced the whole NA segment of isolated virus from influenza patients and investigated the relation between the NA amino acid sequence and the 50%...
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