A Homer 1 gene variant influences brain structure and function, lithium effects on white matter, and antidepressant response in bipolar disorder: A multimodal genetic imaging study.

doi:10.1016/j.pnpbp.2017.10.011

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Article

A Homer 1 gene variant influences brain structure and function, lithium effects on white matter, and antidepressant response in bipolar disorder: A multimodal genetic imaging study.

Progress in neuro-psychopharmacology & biological psychiatry - 2 Feb 2018

Benedetti Francesco, Poletti Sara, Locatelli Clara, Mazza Elena, Lorenzi Cristina, Vitali Alice, Riberto Martina, Brioschi Silvia, Vai Benedetta, Bollettini Irene, Melloni Elisa, Aggio Veronica, Falini Andrea, De Bartolomeis Andrea, Colombo Cristina

Abstract excerpt

BACKGROUND: The Homer family of postsynaptic scaffolding proteins plays a crucial role in glutamate-mediated synaptic plasticity, a phenotype associated with Bipolar Disorder (BD). Homer is a target for antidepressants and mood stabilizers. The AA risk genotype of the Homer rs7713917 A>G SNP has been associated with mood disorders and suicide, and in healthy humans with brain function. Despite the evidence...

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PMID: 29079138
DOI: 10.1016/j.pnpbp.2017.10.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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