Article
Genomic analysis of the origins and evolution of multicentric diffuse lower-grade gliomas.
Neuro-oncology - 9 Apr 2018
Hayes Josie, Yu Yao, Jalbert Llewellyn E, Mazor Tali, Jones Lindsey E, Wood Matthew D, Walsh Kyle M, Bengtsson Henrik, Hong Chibo, Oberndorfer Stefan, Roetzer Thomas, Smirnov Ivan V, Clarke Jennifer L, Aghi Manish K, Chang Susan M, Nelson Sarah J, Woehrer Adelheid, Phillips Joanna J, Solomon David A, Costello Joseph F
Abstract excerpt
Background: Rare multicentric lower-grade gliomas (LGGs) represent a unique opportunity to study the heterogeneity among distinct tumor foci in a single patient and to infer their origins and parallel patterns of evolution. Methods: In this study, we integrate clinical features, histology, and immunohistochemistry for 4 patients with multicentric LGG, arising both synchronously and metachronously. For 3 patients...
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