Article
The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population.
Human molecular genetics - 1 Jul 2011
Terao Chikashi, Yamada Ryo, Ohmura Koichiro, Takahashi Meiko, Kawaguchi Takahisa, Kochi Yuta, Okada Yukinori, Nakamura Yusuke, Yamamoto Kazuhiko, Melchers Inga, Lathrop Mark, Mimori Tsuneyo, Matsuda Fumihiko
Abstract excerpt
Rheumatoid arthritis (RA) is a typical complex trait and the major cause of chronic inflammation worldwide. Although multiple genetic loci have been shown for their association with the onset of RA, they cover only a part of its genetic components and are largely ethnicity-specific. To identify novel genetic factors related to the predisposition and prognosis of RA in Japanese, we conducted a large-scale...
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