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Article

Role of the autoimmune regulator (AIRE) gene in alopecia areata: strong association of a potentially functional AIRE polymorphism with alopecia universalis.

Tissue antigens - 1 Dec 2002

Tazi-Ahnini R, Cork M J, Gawkrodger D J, Birch M P, Wengraf D, McDonagh A J G, Messenger A G

Abstract excerpt

Alopecia areata is characterized by a reversible form of patchy or complete hair loss associated with T-cell infiltration of hair follicles. The lifetime disease risk of approximately 1.4% in the general population is increased to more than 30% in autoimmune polyendocrinopathy candidiasis ectodermal dysplasia syndrome (APECED), a recessive condition resulting from a mutation of the autoimmune regulator (AIRE)...

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Source

Identifiers

PMID: 12542742
DOI: 10.1034/j.1399-0039.2002.600604.x

Genes

AIRE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of the autoimmune regulator (AIRE) gene in alopecia areata: strong association of a potentially functional AIRE polymorphism with alopecia universalis.PMID 12542742Read ↗

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Functional analysis of SAND mutations in AIRE supports dominant inheritance of the G228W mutation.Semantic proximity Read ↗

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Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.Semantic proximity Read ↗

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