Article
Endogenous antibody responses to mucin 1 in a large multiethnic cohort of patients with breast cancer and healthy controls: Role of immunoglobulin and Fcγ receptor genes.
Immunobiology - 1 Feb 2018
Pandey Janardan P, Namboodiri Aryan M, Wolf Bethany, Iwasaki Motoki, Kasuga Yoshio, Hamada Gerson S, Tsugane Shoichiro
Abstract excerpt
High levels of naturally occurring IgG antibodies to mucin 1 (MUC1), a membrane-bound glycoprotein that is overexpressed in patients with breast cancer, are associated with good prognosis. This suggests that endogenous anti-MUC1 antibodies have a protective effect and, through antibody-mediated host immunosurveillance mechanisms, might contribute to a cancer-free state. To test this possibility, we characterized...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.