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Article

Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways.

Science translational medicine - 25 Oct 2017

Saito Yoriko, Mochizuki Yoshiki, Ogahara Ikuko, Watanabe Takashi, Hogdal Leah, Takagi Shinsuke, Sato Kaori, Kaneko Akiko, Kajita Hiroshi, Uchida Naoyuki, Fukami Takehiro, Shultz Leonard D, Taniguchi Shuichi, Ohara Osamu, Letai Anthony G, Ishikawa Fumihiko

Abstract excerpt

Numerous variant alleles are associated with human acute myeloid leukemia (AML). However, the same variants are also found in individuals with no hematological disease, making their functional relevance obscure. Through NOD.Cg-PrkdcscidIl2rgtmlWjl/Sz (NSG) xenotransplantation, we functionally identified preleukemic and leukemic stem cell populations present in FMS-like tyrosine kinase 3 internal tandem...

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Source

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Identifiers

PMID: 29070697
DOI: 10.1126/scitranslmed.aao1214
PMCID: PMC6377281

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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