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Article

Gene Expression Profiling of Large Cell Lung Cancer Links Transcriptional Phenotypes to the New Histological WHO 2015 Classification.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Aug 2017

Karlsson Anna, Brunnström Hans, Micke Patrick, Veerla Srinivas, Mattsson Johanna, La Fleur Linnea, Botling Johan, Jönsson Mats, Reuterswärd Christel, Planck Maria, Staaf Johan

Abstract excerpt

INTRODUCTION: Large cell lung cancer (LCLC) and large cell neuroendocrine carcinoma (LCNEC) constitute a small proportion of NSCLC. The WHO 2015 classification guidelines changed the definition of the debated histological subtype LCLC to be based on immunomarkers for adenocarcinoma and squamous cancer. We sought to determine whether these new guidelines also translate into the transcriptional landscape of lung...

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PMID: 28535939
DOI: 10.1016/j.jtho.2017.05.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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