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Article

Chronic hepatitis B carriers with acute on chronic liver failure show increased HBV surface gene mutations, including immune escape variants.

Virology journal - 24 Oct 2017

Gao Shan, Joshi Shivali S, Osiowy Carla, Chen Y, Coffin Carla S, Duan Z-P

Abstract excerpt

BACKGROUND: The pathogenesis of acute-on-chronic liver failure (ACLF) in chronic hepatitis B (CHB) is not well understood. The aim of this study was to investigate whether there is an association between HBV polymerase (P)/overlapping surface (S) gene and basal core promoter (BCP)/precore (PC) variants and development of ACLF in CHB. METHODS: Two CHB patient cohorts were compared: (i) ACLF (N = 12) (11/12 M,...

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Identifiers

PMID: 29065883
DOI: 10.1186/s12985-017-0870-x
PMCID: PMC5655973

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