Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation of Asn-475 in the Venezuelan Equine Encephalitis Virus nsP2 Cysteine Protease Leads to a Self-Inhibited State.

Biochemistry - 28 Nov 2017

Compton Jaimee R, Mickey Matthew J, Hu Xin, Marugan Juan J, Legler Patricia M

Abstract excerpt

The alphaviral nsP2 cysteine protease of the Venezuelan equine encephalitis virus (VEEV) is a validated antiviral drug target. Clan CN proteases contain a cysteine protease domain that is intimately packed with an S-adenosyl-l-methionine-dependent RNA methyltransferase (SAM MTase) domain. Within a cleft formed at the interface of these two domains, the peptide substrate is thought to bind. The nucleophilic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding, Competitive
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crystallography, X-Ray

Share to Cysteine Endopeptidases

Share to Feedback, Physiological

Share to Hydrolysis

Share to Sequence Homology

Share to Viral Proteins

Source

Identifiers

PMID: 29064679
DOI: 10.1021/acs.biochem.7b00746

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation of Asn-475 in the Venezuelan Equine Encephalitis Virus nsP2 Cysteine Protease Leads to a Self-Inhibited State.PMID 29064679Read ↗

Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease.Semantic proximity Read ↗

Site-directed mutagenesis and kinetic studies of the West Nile Virus NS3 protease identify key enzyme-substrate interactions.Semantic proximity Read ↗

Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease.Semantic proximity Read ↗

Mutational scan of self-cleavage by HIV-1 protease provides new views of a conformationally dynamic mechanism.Semantic proximity Read ↗

Structural basis of inactivation of human counterpart of mouse motor neuron degeneration 2 mutant in serine protease HtrA2.Semantic proximity Read ↗

Arterivirus nsp12 versus the coronavirus nsp16 2′-O-methyltransferase: comparison of the C-terminal cleavage products of two nidovirus pp1ab polyproteinsSemantic proximity Read ↗

Navigation inside a protease: substrate selection and product exit in the tricorn protease from Thermoplasma acidophilum.Semantic proximity Read ↗

Molecular basis of prodrug activation by human valacyclovirase, an alpha-amino acid ester hydrolase.Semantic proximity Read ↗

Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes.Semantic proximity Read ↗

Mechanism of Mutation-Induced Effects on the Catalytic Function of TEV Protease: A Molecular Dynamics Study.Semantic proximity Read ↗

Kinetic characterization of human immunodeficiency virus type-1 protease-resistant variants.Semantic proximity Read ↗

Regulation of autoproteolysis of the HIV-1 and HIV-2 proteases with engineered amino acid substitutionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.