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Article

Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease.

Biochemistry - 31 May 2016

Hu Xin, Compton Jaimee R, Leary Dagmar H, Olson Mark A, Lee Michael S, Cheung Jonah, Ye Wenjuan, Ferrer Mark, Southall Noel, Jadhav Ajit, Morazzani Elaine M, Glass Pamela J, Marugan Juan, Legler Patricia M

Abstract excerpt

The Venezuelan equine encephalitis virus (VEEV) nonstructural protein 2 (nsP2) cysteine protease (EC 3.4.22.-) is essential for viral replication and is involved in the cytopathic effects (CPE) of the virus. The VEEV nsP2 protease is a member of MEROPS Clan CN and characteristically contains a papain-like protease linked to an S-adenosyl-l-methionine-dependent RNA methyltransferase (SAM MTase) domain. The...

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Identifiers

PMID: 27030368
DOI: 10.1021/acs.biochem.5b00992
PMCID: PMC5290728

Genes

CPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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