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Article

Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity.

Diabetes - 1 Jan 2018

Norris Jill M, Lee Hye-Seung, Frederiksen Brittni, Erlund Iris, Uusitalo Ulla, Yang Jimin, Lernmark Åke, Simell Olli, Toppari Jorma, Rewers Marian, Ziegler Anette-G, She Jin-Xiong, Onengut-Gumuscu Suna, Chen Wei-Min, Rich Stephen S, Sundvall Jouko, Akolkar Beena, Krischer Jeffrey, Virtanen Suvi M, Hagopian William

Abstract excerpt

We examined the association between plasma 25-hydroxyvitamin D [25(OH)D] concentration and islet autoimmunity (IA) and whether vitamin D gene polymorphisms modify the effect of 25(OH)D on IA risk. We followed 8,676 children at increased genetic risk of type 1 diabetes at six sites in the U.S. and Europe. We defined IA as positivity for at least one autoantibody (GADA, IAA, or IA-2A) on two or more visits. We...

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Identifiers

PMID: 29061729
DOI: 10.2337/db17-0802
PMCID: PMC5741144

Genes

VDR
RXRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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