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Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study.

Diabetes care - 1 May 2023

Thorsen Steffen U, Liu Xiang, Kataria Yachana, Mandrup-Poulsen Thomas, Kaur Simranjeet, Uusitalo Ulla, Virtanen Suvi M, Norris Jill M, Rewers Marian, Hagopian William, Yang Jimin, She Jin-Xiong, Akolkar Beena, Rich Stephen, Aronsson Carin Andrén, Lernmark Åke, Ziegler Anette-Gabriele, Toppari Jorma, Krischer Jeffrey, Parikh Hemang M, Ellervik Christina, Svensson Jannet

Abstract excerpt

OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D....

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Autoantibodies
Autoimmunity
Diabetes Mellitus, Type 1
Infant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Islets of Langerhans

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PMID: 36867433
DOI: 10.2337/dc22-1359
PMCID: PMC10154662

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