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Article

Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype.

The Journal of cell biology - 25 Apr 2016

Capote Joana, Kramerova Irina, Martinez Leonel, Vetrone Sylvia, Barton Elisabeth R, Sweeney H Lee, Miceli M Carrie, Spencer Melissa J

Abstract excerpt

In the degenerative disease Duchenne muscular dystrophy, inflammatory cells enter muscles in response to repetitive muscle damage. Immune factors are required for muscle regeneration, but chronic inflammation creates a profibrotic milieu that exacerbates disease progression. Osteopontin (OPN) is an immunomodulator highly expressed in dystrophic muscles. Ablation of OPN correlates with reduced fibrosis and...

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Identifiers

PMID: 27091452
DOI: 10.1083/jcb.201510086
PMCID: PMC5084275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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