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Article

Is normal hematopoiesis maintained solely by long-term multipotent stem cells?

8 Feb 2011

Abstract excerpt

The understanding of the hierarchical organization of the human hematopoietic system is of major biologic and clinical significance. The validity of the conventional model in which hematopoiesis is solely maintained by a pool of multipotent long-term hematopoietic stem cells (LT-HSCs) has been recently challenged by several mouse studies. These new data point to the existence of a heterogeneous stem cell...

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PMID: 21304104
DOI: 10.1182/blood-2010-09-255679

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