Article
Development of 3D culture models of plexiform neurofibroma and initial application for phenotypic characterization and drug screening.
Experimental neurology - 1 Jan 2018
Kraniak Janice M, Chalasani Anita, Wallace Margaret R, Mattingly Raymond R
Abstract excerpt
Plexiform neurofibromas (PNs), which may be present at birth in up to half of children with type 1 neurofibromatosis (NF1), can cause serious loss of function, such as quadriparesis, and can undergo malignant transformation. Surgery is the first line treatment although the invasive nature of these tumors often prevents complete resection. Recent clinical trials have shown promising success for some drugs, notably...
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