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Article

Mechanical Stiffening Promotes Growth, Invasion-Associated Phenotypes, and Reduced Selumetinib Sensitivity in 3D Plexiform Neurofibroma Cultures.

Cells - 12 May 2026

Ji Kyungmin, Shi Chenjun, Zhang Jitao, Mattingly Raymond R

Abstract excerpt

Plexiform neurofibromas (pNF1s) are benign peripheral nerve sheath tumors caused by NF1 loss, leading to dysregulated RAS/mitogen-activated protein kinase (MAPK) signaling. While the mitogen-activated protein kinase kinase (MEK) inhibitors, selumetinib and mirdametinib, can reduce tumor volume, surgical resection remains the primary treatment for immediate debulking and symptom relief. Complete removal is often...

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Identifiers

PMID: 42193887
DOI: 10.3390/cells15100877
PMCID: PMC13204610

Genes

NF1
LOX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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