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iPSC-derived <i>NF1</i> - <i>CDKN2A</i> -PRC2 deficient neural crest mimics MPNST glial-to-neuro-mesenchymal transition and uncover new therapeutic opportunities

2025-08-15

Abstract excerpt

Neurofibromatosis Type 1 (NF1) predisposes to peripheral nerve tumor development. Commonly, the progression from a benign plexiform neurofibroma (PNF) towards a deadly malignant peripheral nerve sheath tumor (MPNST) involves a poorly understood glial-to-mesenchymal transition and the sequential loss of NF1, CDKN2A , and polycomb repressive complex 2 (PRC2). Using an iPSC-derived neural crest (NC) model, we reprod...

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Literature Corpus work
cbeafe36-e1c7-5801-af55-30c856bd01b2
DOI
10.1101/2025.08.13.670072
Open publication

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