Article
Existing and Developing Preclinical Models for Neurofibromatosis Type 1-Related Cutaneous Neurofibromas.
The Journal of investigative dermatology - 1 Aug 2023
Staedtke Verena, Topilko Piotr, Le Lu Q, Grimes Kevin, Largaespada David A, Cagan Ross L, Steensma Matthew R, Stemmer-Rachamimov Anat, Blakeley Jaishri O, Rhodes Steven D, Ly Ina, Romo Carlos G, Lee Sang Y, Serra Eduard
Abstract excerpt
Neurofibromatosis type 1 (NF1) is caused by a nonfunctional copy of the NF1 tumor suppressor gene that predisposes patients to the development of cutaneous neurofibromas (cNFs), the skin tumor that is the hallmark of this condition. Innumerable benign cNFs, each appearing by an independent somatic inactivation of the remaining functional NF1 allele, form in nearly all patients with NF1. One of the limitations in...
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