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Article

Contribution of Extra-Cardiac Cells in Murine Heart Valves is Age-Dependent.

Journal of the American Heart Association - 20 Oct 2017

Anstine Lindsey J, Horne Tori E, Horwitz Edwin M, Lincoln Joy

Abstract excerpt

BACKGROUND: Heart valves are dynamic structures that open and close over 100 000 times a day to maintain unidirectional blood flow during the cardiac cycle. Function is largely achieved by highly organized layers of extracellular matrix that provide the necessary biomechanical properties. Homeostasis of valve extracellular matrix is mediated by valve endothelial and interstitial cell populations, and although the...

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Identifiers

PMID: 29054843
DOI: 10.1161/JAHA.117.007097
PMCID: PMC5721893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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