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Article

Time-controllable Nkcc1 knockdown replicates reversible hearing loss in postnatal mice.

Scientific reports - 19 Oct 2017

Watabe Takahisa, Xu Ming, Watanabe Miho, Nabekura Junichi, Higuchi Taiga, Hori Karin, Sato Mitsuo P, Nin Fumiaki, Hibino Hiroshi, Ogawa Kaoru, Masuda Masatsugu, Tanaka Kenji F

Abstract excerpt

Identification of the causal effects of specific proteins on recurrent and partially reversible hearing loss has been difficult because of the lack of an animal model that provides reversible gene knockdown. We have developed the transgenic mouse line Actin-tTS::Nkcc1 tetO/tetO for manipulatable expression of the cochlear K+ circulation protein, NKCC1. Nkcc1 transcription was blocked by the binding of a...

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Identifiers

PMID: 29051615
DOI: 10.1038/s41598-017-13997-7
PMCID: PMC5648887

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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