Article
Effect of Specific Mutations in Cd300 Complexes Formation; Potential Implication of Cd300f in Multiple Sclerosis.
Scientific reports - 19 Oct 2017
Martínez-Barriocanal Águeda, Arcas-García Andrea, Magallon-Lorenz Miriam, Ejarque-Ortíz Aroa, Negro-Demontel María Luciana, Comas-Casellas Emma, Schwartz Simo, Malhotra Sunny, Montalban Xavier, Peluffo Hugo, Martín Margarita, Comabella Manuel, Sayós Joan
Abstract excerpt
Herein, we have used bioinformatics tools to predict five clusters defining ligand-binding sites on the extracellular domain of human CD300b receptor, presumably involved in the formation of both homodimers and heterodimers with other CD300 family members. Site-directed mutagenesis revealed residues glutamic acid 28 and glutamine 29 in cluster 5 to be necessary for the formation of CD300b complexes. Surprisingly,...
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