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Article

The homozygous CX3CR1-M280 mutation impairs human monocyte survival.

JCI insight - 8 Feb 2018

Collar Amanda L, Swamydas Muthulekha, O'Hayre Morgan, Sajib Md Sanaullah, Hoffman Kevin W, Singh Satya P, Mourad Ahmad, Johnson Melissa D, Ferre Elise Mn, Farber Joshua M, Lim Jean K, Mikelis Constantinos M, Gutkind J Silvio, Lionakis Michail S

Abstract excerpt

Several reports have demonstrated that mouse Cx3cr1 signaling promotes monocyte/macrophage survival. In agreement, we previously found that, in a mouse model of systemic candidiasis, genetic deficiency of Cx3cr1 resulted in increased mortality and impaired tissue fungal clearance associated with decreased macrophage survival. We translated this finding by showing that the dysfunctional CX3CR1 variant CX3CR1-M280...

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Identifiers

PMID: 29415879
DOI: 10.1172/jci.insight.95417
PMCID: PMC5821174

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