Article
Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models.
Haematologica - 1 Jan 2018
Wang Jieyu, Hayashi Yoshihiro, Yokota Asumi, Xu Zefeng, Zhang Yue, Huang Rui, Yan Xiaomei, Liu Hongyun, Ma Liping, Azam Mohammad, Bridges James P, Cancelas Jose A, Kalfa Theodosia A, An Xiuli, Xiao Zhijian, Huang Gang
Abstract excerpt
Activated erythropoietin (EPO) receptor (EPOR) signaling causes erythrocytosis. The important role of macrophages for the erythroid expansion and differentiation process has been reported, both in baseline and stress erythropoiesis. However, the significance of EPOR signaling for regulation of macrophages contributing to erythropoiesis has not been fully understood. Here we show that EPOR signaling activation...
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