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Dexamethasone targeted directly to macrophages induces macrophage niches that promote erythroid expansion

22 Dec 2014

Abstract excerpt

Cultures of human CD34(pos) cells stimulated with erythroid growth factors plus dexamethasone, a model for stress erythropoiesis, generate numerous erythroid cells plus a few macrophages (approx. 3%; 3:1 positive and negative for CD169). Interactions occurring between erythroblasts and macrophages in these cultures and the biological effects associated with these interactions were documented by live...

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PMID: 25533803
DOI: 10.3324/haematol.2014.114405

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