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CISH controls bacterial burden early after infection with Mycobacterium tuberculosis in mice.

Tuberculosis (Edinburgh, Scotland) - 1 Dec 2017

Carow Berit, Gao Yu, Terán Graciela, Yang Xuexian O, Dong Chen, Yoshimura Akihiko, Rottenberg Martin E

Abstract excerpt

CISH gene has been associated with increased susceptibility to human tuberculosis. We found that cish-/- mice had higher M. tuberculosis load in spleens and lungs up to 2.5 weeks after infection but not later compared to controls. Cish mRNA levels were increased in lungs at early and late time points after M. tuberculosis infection. In relation, the titers of inos and tnf mRNA in lungs were reduced early after...

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Source

Identifiers

PMID: 29050767
DOI: 10.1016/j.tube.2017.09.007

Genes

CISH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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