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Article

Mycobacterium tuberculosis EsxL inhibits MHC-II expression by promoting hypermethylation in class-II transactivator loci in macrophages.

The Journal of biological chemistry - 28 Apr 2017

Sengupta Srabasti, Naz Saba, Das Ishani, Ahad Abdul, Padhi Avinash, Naik Sumanta Kumar, Ganguli Geetanjali, Pattanaik Kali Prasad, Raghav Sunil Kumar, Nandicoori Vinay Kumar, Sonawane Avinash

Abstract excerpt

Mycobacterium tuberculosis is known to modulate the host immune responses to facilitate its persistence inside the host cells. One of the key mechanisms includes repression of class-II transactivator (CIITA) and MHC-II expression in infected macrophages. However, the precise mechanism of CIITA and MHC-II down-regulation is not well studied. M. tuberculosis 6-kDa early secretory antigenic target (ESAT-6) is a...

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PMID: 28209712
DOI: 10.1074/jbc.M117.775205
PMCID: PMC5409457

Genes

CIITA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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