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Engineering Nanodisc Scaffold Proteins for Native Mass Spectrometry.

Analytical chemistry - 7 Nov 2017

Reid Deseree J, Keener James E, Wheeler Andrew P, Zambrano Dane Evan, Diesing Jessica M, Reinhardt-Szyba Maria, Makarov Alexander, Marty Michael T

Abstract excerpt

Lipoprotein nanodiscs are ideally suited for native mass spectrometry because they provide a relatively monodisperse nanoscale lipid bilayer environment for delivering membrane proteins into the gas phase. However, native mass spectrometry of nanodiscs produces complex spectra that can be challenging to assign unambiguously. To simplify interpretation of nanodisc spectra, we engineered a series of mutant membrane...

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PMID: 29048874
DOI: 10.1021/acs.analchem.7b03569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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