Article
MECOM, HBS1L-MYB, THRB-RARB, JAK2, and TERT polymorphisms defining the genetic predisposition to myeloproliferative neoplasms: A study on 939 patients.
American journal of hematology - 1 Jan 2018
Trifa Adrian P, Bănescu Claudia, Bojan Anca S, Voina Cristian M, Popa Ștefana, Vișan Simona, Ciubean Alina D, Tripon Florin, Dima Delia, Popov Viola M, Vesa Ștefan C, Andreescu Mihaela, Török-Vistai Tünde, Mihăilă Romeo G, Berbec Nicoleta, Macarie Ioan, Coliţă Andrei, Iordache Maria, Cătană Alina C, Farcaș Marius F, Tomuleasa Ciprian, Vasile Kinga, Truică Cristina, Todincă Adriana, Pop-Muntean Lavinia, Manolache Raluca, Bumbea Horia, Vlădăreanu Ana-Maria, Gaman Mihaela, Ciufu Cristina M, Popp Radu A
Abstract excerpt
Polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) are classical myeloproliferative neoplasms (MPN), characterized by specific somatic mutations in JAK2, CALR or MPL genes. JAK2 46/1 and TERT rs2736100 polymorphisms are known to significantly predispose to MPN. This study aimed to establish the additional contribution of the recently described MECOM rs2201862, HBS1L-MYB...
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