Article
Imputation of missing genotypes within LD-blocks relying on the basic coalescent and beyond: consideration of population growth and structure.
BMC genomics - 17 Oct 2017
Kabisch Maria, Hamann Ute, Lorenzo Bermejo Justo
Abstract excerpt
BACKGROUND: Genotypes not directly measured in genetic studies are often imputed to improve statistical power and to increase mapping resolution. The accuracy of standard imputation techniques strongly depends on the similarity of linkage disequilibrium (LD) patterns in the study and reference populations. Here we develop a novel approach for genotype imputation in low-recombination regions that relies on the...
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