Article
Maternal and zygotic activity of the zebrafish ogon locus antagonizes BMP signaling.
Developmental biology - 1 Oct 1999
Miller-Bertoglio V, Carmany-Rampey A, Fürthauer M, Gonzalez E M, Thisse C, Thisse B, Halpern M E, Solnica-Krezel L
Abstract excerpt
The dorsal-ventral axis of vertebrate embryos is thought to be specified by a gradient of bone morphogenetic protein (BMP) activity, which, in part, arises through the interaction of dorsally expressed antagonists Chordin and Noggin with the ventralizing BMPs. The zebrafish mercedes(tm305), ogon(m60), and short tail(b180) mutations produce ventralized phenotypes, including expanded bmp2b/4 expression domains. We...
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