Article
Site-specific functionality and tryptophan mimicry of lipidation in tetraspanin CD9.
The FEBS journal - 1 Dec 2020
Neviani Viviana, van Deventer Sjoerd, Wörner Tobias P, Xenaki Katerina T, van de Waterbeemd Michiel, Rodenburg Remco N P, Wortel Inge M N, Kuiper Jeroen K, Huisman Sofie, Granneman Joke, van Bergen En Henegouwen Paul M P, Heck Albert J R, van Spriel Annemiek B, Gros Piet
Abstract excerpt
Lipidation of transmembrane proteins regulates many cellular activities, including signal transduction, cell-cell communication, and membrane trafficking. However, how lipidation at different sites in a membrane protein affects structure and function remains elusive. Here, using native mass spectrometry we determined that wild-type human tetraspanins CD9 and CD81 exhibit nonstochastic distributions of bound acyl...
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