Article
ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway.
Cell - 29 Jun 1990
Semenza J C, Hardwick K G, Dean N, Pelham H R
Abstract excerpt
Resident proteins of the ER lumen carry a specific tetrapeptide signal (KDEL or HDEL) that prevents their secretion. We have previously described the isolation of yeast mutants that fail to retain such resident proteins within the cell. Here we describe ERD2, a gene required for retention. It encodes a 26 kd integral membrane protein whose abundance determines the efficiency and capacity of the retention system....
Topics
- Amino Acid Sequence
- Base Sequence
- Endoplasmic Reticulum
- Fungal Proteins
- Genes, Fungal
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Plasmids
- Protein Conformation
- Receptors, Peptide