Article
Vascular Calcification Is Accelerated by Hyponatremia and Low Osmolality.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2024
Matsueda Shumei, Yamada Shunsuke, Torisu Kumiko, Kitamura Hiromasa, Ninomiya Toshiharu, Nakano Toshiaki, Kitazono Takanari
Abstract excerpt
BACKGROUND: Hyponatremia, frequently observed in patients with chronic kidney disease, is associated with increased cardiovascular morbidity and mortality. Hyponatremia or low osmolality induces oxidative stress and cell death, both of which accelerate vascular calcification (VC), a critical phenotype in patients with chronic kidney disease. Whether hyponatremia or low osmolality plays a role in the pathogenesis...
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