Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FOXP3, ICOS and ICOSL gene polymorphisms in systemic sclerosis: FOXP3 rs2294020 is associated with disease progression in a female Italian population.

Immunobiology - 1 Jan 2018

D'Amico Fabio, Fiorito Giovanni, Skarmoutsou Evangelia, Granata Mariagrazia, Rossi Giulio A, Trovato Chiara, Bellocchi Chiara, Marchini Maurizio, Beretta Lorenzo, Mazzarino Maria Clorinda

Abstract excerpt

Systemic sclerosis (SSc), an autoimmune disorder, is characterized by vasculopathy, inflammation, progressive perivascular and interstitial fibrosis. Its pathogenesis is largely unknown, however strong evidences suggest that genetic predisposition may contribute to SSc development. Several gene polymorphisms involved in regulatory T cell function have been identified in many autoimmune diseases, including SSc....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Transcription Factors

Share to Gene Frequency

Share to Genetic Association Studies

Share to Inducible T-Cell Co-Stimulator Protein

Share to Scleroderma, Systemic

Source

Identifiers

PMID: 29030005
DOI: 10.1016/j.imbio.2017.10.004

Genes

FOXP3
ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FOXP3, ICOS and ICOSL gene polymorphisms in systemic sclerosis: FOXP3 rs2294020 is associated with disease progression in a female Italian population.PMID 29030005Read ↗

Genetic polymorphisms of FOXP3 in Italian patients with systemic sclerosis.Semantic proximity Read ↗

Systemic Sclerosis is a Complex Disease Associated Mainly with Immune Regulatory and Inflammatory GenesSemantic proximity Read ↗

Immunogenetics of systemic sclerosis: Defining heritability, functional variants and shared-autoimmunity pathways.Semantic proximity Read ↗

FOXP3 Gene Variants in Patients with Systemic Lupus Erythematosus: Association with Disease Susceptibility in Men and Relationship with Abortion in Women.Semantic proximity Read ↗

Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.Semantic proximity Read ↗

Genetic background of systemic sclerosis: autoimmune genes take centre stage.Semantic proximity Read ↗

The status of pulmonary fibrosis in systemic sclerosis is associated with IRF5, STAT4, IRAK1, and CTGF polymorphisms.Semantic proximity Read ↗

Evidence of the contribution of the X chromosome to systemic sclerosis susceptibility: association with the functional IRAK1 196Phe/532Ser haplotype.Semantic proximity Read ↗

Genomic and genetic studies of systemic sclerosis: A systematic review.Semantic proximity Read ↗

TRAF3IP2 gene and systemic lupus erythematosus: association with disease susceptibility and pericarditis development.Semantic proximity Read ↗

Immunogenetics of systemic sclerosis.Semantic proximity Read ↗

FOXP3 polymorphisms in interstitial lung disease among Chinese Han population: A genetic association study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.