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Article

Phylogenetic evidence for deleterious mutation load in RNA viruses and its contribution to viral evolution.

Molecular biology and evolution - 1 Mar 2007

Pybus Oliver G, Rambaut Andrew, Belshaw Robert, Freckleton Robert P, Drummond Alexei J, Holmes Edward C

Abstract excerpt

Populations of RNA viruses are often characterized by abundant genetic variation. However, the relative fitness of these mutations is largely unknown, although this information is central to our understanding of viral emergence, immune evasion, and drug resistance. Here we develop a phylogenetic method, based on the distribution of nonsynonymous and synonymous changes, to assess the relative fitness of...

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Identifiers

PMID: 17218639
DOI: 10.1093/molbev/msm001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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