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Article

Positive selection drives a correlation between non-synonymous/synonymous divergence and functional divergence.

Bioinformatics (Oxford, England) - 15 Jun 2008

Tennessen Jacob A

Abstract excerpt

MOTIVATION: Functional divergence among proteins is often assumed to be strongly influenced by natural selection, as inferred from the ratio of non-synonymous nucleotide divergence (d(N)) to synonymous nucleotide divergence (d(S)). That is, the more a mutation changes protein function, the more likely it is to be either selected against or selectively favored, and because the d(N)/d(S) ratio is a measure of...

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Identifiers

PMID: 18443017
DOI: 10.1093/bioinformatics/btn205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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