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Article

Proteomic Profiling of β-hCG-Induced Spheres in BRCA1 Defective Triple Negative Breast Cancer Cells.

Journal of proteome research - 5 Jan 2018

Sengodan Satheesh Kumar, Rajan Arathi, Hemalatha Sreelatha Krishnakumar, Nadhan Revathy, Jaleel Abdul, Srinivas Priya

Abstract excerpt

Previously, we identified that β-hCG is expressed by BRCA1 mutated but not wild type breast cancers in vitro/in vivo and exhibited a novel event in β-hCG overexpressing BRCA1 mutated HCC1937 cells where the cells were able to form spheres (HCC1937 β spheres) in adherent cell culture plates even in the absence of any growth factors. These spheres express stem cell and EMT markers. In the present study, we carried...

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Identifiers

PMID: 29028349
DOI: 10.1021/acs.jproteome.7b00562

Genes

BRCA1

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