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Article

Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer.

Oncotarget - 27 Sept 2016

Warmoes Marc, Lam Siu W, van der Groep Petra, Jaspers Janneke E, Smolders Yvonne H C M, de Boer Leon, Pham Thang V, Piersma Sander R, Rottenberg Sven, Boven Epie, Jonkers Jos, van Diest Paul J, Jimenez Connie R

Abstract excerpt

Breast cancer arising in female BRCA1 mutation carriers is characterized by an aggressive phenotype and early age of onset. We performed tandem mass spectrometry-based proteomics of secretomes and exosome-like extracellular vesicles from BRCA1-deficient and BRCA1-proficient murine breast tumor models to identify extracellular protein biomarkers, which can be used as an adjunct to current diagnostic modalities in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27566577
DOI: 10.18632/oncotarget.11535
PMCID: PMC5325383

Genes

BRCA1
CDH3
TOP1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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