HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization.

doi:10.1093/ije/dyx189

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Article

HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization.

International journal of epidemiology - 1 Dec 2017

Fan Qiao, Maranville Joseph C, Fritsche Lars, Sim Xueling, Cheung Chui Ming Gemmy, Chen Li Jia, Gorski Mathias, Yamashiro Kenji, Ahn Jeeyun, Laude Augustinus, Dorajoo Rajkumar, Lim Tock Han, Teo Yik-Ying, Blaustein Robert O, Yoshimura Nagahisa, Park Kyu-Hyung, Pang Chi Pui, Tai E Shyong, Khor Chiea Chuen, Wong Tien Yin, Runz Heiko, Cheng Ching-Yu

Abstract excerpt

Background: Dyslipidemia, particularly high-density lipoprotein cholesterol (HDL-C), has recently been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of vision loss. However, epidemiological studies have yielded conflicting results. Methods: We investigated the causal role of plasma lipid levels in AMD in multiethnic populations comprising 16 144 advanced AMD cases and...

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PMID: 29025108
DOI: 10.1093/ije/dyx189
PMCID: PMC5837540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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