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Article

Omega-3 Fatty Acids as Protective Factors for Age-Related Macular Degeneration: Prospective Cohort and Mendelian Randomization Analyses.

Ophthalmology - 1 May 2025

Xue Can Can, Li Hengtong, Yu Marco, Chong Crystal Chun Yuen, Fan Qiao, Tham Yih-Chung, Cheung Chui Ming Gemmy, Wong Tien Yin, Chew Emily Y, Cheng Ching-Yu

Abstract excerpt

PURPOSE: Epidemiologic studies and clinical trials have reported inconsistent findings regarding omega-3 fatty acids' protective role in age-related macular degeneration (AMD). We investigated their association in a prospective cohort and examined causality using Mendelian randomization (MR) analyses. DESIGN: Prospective cohort study and 2-sample MR analyses. PARTICIPANTS: The cohort included 258 350 AMD-free...

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Identifiers

PMID: 39662686
DOI: 10.1016/j.ophtha.2024.12.005
PMCID: PMC12126274

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