Article
Targeted sequencing of 96 renal developmental microRNAs in 1213 individuals from 980 families with congenital anomalies of the kidney and urinary tract.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Aug 2016
Kohl Stefan, Chen Jing, Vivante Asaf, Hwang Daw-Yang, Shril Shirlee, Dworschak Gabriel C, Van Der Ven Amelie, Sanna-Cherchi Simone, Bauer Stuart B, Lee Richard S, Soliman Neveen A, Kehinde Elijah O, Reutter Heiko M, Tasic Velibor, Hildebrandt Friedhelm
Abstract excerpt
BACKGROUND: Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of chronic kidney diseases in children and young adults, accounting for ∼50% of cases. These anomalies represent maldevelopment of the genitourinary system and can be genetically explained in only 10-16% of cases by mutations or by copy number variations in protein coding sequences. Knock-out mouse models, lacking...
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