Article
HLA-DR, -DQ DNA genotyping and T-cell receptor RFLPs in leprosy.
Disease markers - 1 Jan 2000
Jazwinska E C, Serjeantson S W
Abstract excerpt
HLA-DR and -DQ restriction fragment length polymorphisms (RFLPs) were examined in Melanesian leprosy patients and controls from New Caledonia. This permitted DNA subtyping of DQw1, a broad serological specificity previously implicated in predisposition to lepromatous leprosy. The DQw1c subtype, found in linkage disequilibrium with DR1, w10, w14, and some Pacific Island variants of DRw6 and DRw8, was significantly...
Topics
- Crystallins
- DNA
- Genes, MHC Class II
- Genetic Markers
- Genotype
- HLA-DQ Antigens
- HLA-DR Antigens
- Humans
- Leprosy
- Polymorphism, Restriction Fragment Length
- Receptors, Antigen, T-Cell