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Altered Volatile Organic Compound Profile in Transgenic Rats Bearing A53T Mutation of Human α-Synuclein: Comparison with Dopaminergic and Serotonergic Denervation.

ACS chemical neuroscience - 21 Feb 2018

Finberg John P M, Aluf Yuval, Loboda Yelena, Nakhleh Morad K, Jeries Raneen, Abud-Hawa Manal, Zubedat Salman, Avital Avi, Khatib Soliman, Vaya Jacob, Haick Hossam

Abstract excerpt

Early diagnosis of Parkinson's disease (PD) is of great importance due its progressive phenotype. Neuroprotective drugs could potentially slow down disease progression if used at early stages. Previously, we have reported an altered content of volatile organic compounds (VOCs) in the breath of rats following a 50% reduction in striatal dopamine (DA) content induced by 6-hydroxydopamine. We now report on the...

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PMID: 29017011
DOI: 10.1021/acschemneuro.7b00318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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